Peg-Mgf: Inducing Splenocytes To Regenerate Thymus

May 18 2018

PEG MGF refers to mechano growth factor or IGF-1Ec. When it naturally occurs in the body this is a repair or growth factor that is created in damaged or exercised muscle tissue, as a means of creating repairs. This can also be used by the body to stimulate muscle growth. Synthetic versions of this chemical are being derived for research both into muscle growth and its chemicals function and as a potential means of controlling these reactions at the pharmaceutical level in the future.

MGF chemicals are capable of initiating muscle satellite cells and their IGF-receptors to start protein synthesis. If this reaction is triggered properly it can cause an animal to start producing new skeletal muscle. PEG MGF  from is ideal for this purpose because it does not trigger a release of a second version of MGF from the liver that is not always desired in research settings. This also reduces the risk of damaging the animal’s liver with long-term applications of this chemical during research studies.

Neurodegenration which causes structure and function damage to neurons is being investigated to determine if there is further potential for developing therapeutic methods of combating this condition.

Studies utilizing peptides, including pegylated formulations of siRNA delivery, can be administered intranasally which may pass the brain-blood barrier.

Studies are currently investigating the optimal applications for these peptides, the duration for which they can be administered, how they are dispersed in the body and potential toxicity of these chemicals.

Results have indicated that siRNA can be successfully delivered to the hippocampus, hypothalamus, thalamus and Prukinje cells within the cerebellum within 4 hours.

These results further indicate that these chemicals can be applied to the brain without causing toxic effects in other tissues. This may pave the road for future treatment of neurological disorders with intranasal chemical applications.

Inducing Splenocytes that May Regenerate the Thymus

Cytokine regulation of T-lymphoid progenitor cell proliferation has not yet been well defined, so research focused on identifying hemopoietic growth factors and stem cell factors.

These factors helped to identify a transplant model of thymocyte regeneration that could be used to access effects of SCF in vivo of thymocyte or prethymic progenitor cell activity.

This research revealed that recombinant rat SCF that is administered to rats that are weaning in selective administration induced increases in thymocyte progenitor activity in their spleens.

This data further indicates that administering SCF in vivo can affect the extrathymic origin of thymocite regeneration and could affect the prethymic stages of T-cell lymphopoiesis.


Activities in the Brains of Rats

The value of measuring insecticide levels in carbaryl-poisoned rats was studied to better understand these effects on the brain.

Mature rats were administered 1200, 800 or 450mg of carbaryl orally or carbaryl resides in the heart, brain liver. Cholinesterase activity was measured in the blood cells, brain and plasma of dead rats.

Tissue residue was still present 24-48 hours after the initial chemicals were applied. The brain’s ChE activity was less than 35 percent of normal levels. Surviving rats had 55 percent of normal ChE activities within 48 hours of the chemical administration. Blood and plasma levels were normal.

Cholinerterase activities in these tissues returned to 70 percent 96 hours after the application of the chemicals. Studies of the gastrointestinal tract revealed that prolonged absorption of these chemicals could account for some of the side effects seen.

MGF can be considered a highly anabolic version of IGF based chemicals with MGF causing hypertrophy and helping with the repair of localized muscle tissue in animals. It can be used to trigger a stem cell reaction or anabolic processes necessary to maintain natural muscle tissue in animals, like Rats, via nitrogen retention or protein synthesis.